Faye M. Rosin

Faye M. Rosin

Faye M. Rosin

Director of Research Facilitation

1300 Centre Street
Boston, MA 02131
Phone: 617.384.5095
Fax: 617.384.6596
Email

Education

PhD Molecular, Cellular, and Developmental Biology, Iowa State University
BS Environmental Science and Biotechnology, Minnesota State University

My research interests focus on understanding how gene expression is regulated and the consequences of that regulation at the molecular, cellular, and developmental levels. My research at Iowa State University and at Plant Research International in the Netherlands concentrated on transcription factors and their role in developmental processes by the mediation of hormone or metabolite levels. Changes in the concentration or location of these transcription factors altered the initiation and development of the potato tuber and maturation of the tomato fruit. Next, I focused on the role the cell plays in the regulation of gene expression. Using a collection of plants with fluorescently tagged chromosome regions, we found that the physical location of the gene within the nucleus directly affected the expression of the gene. During my time at Harvard University, I turned my attention to the evolution of floral development. Rather than examining individual genes, I tracked thousands of genes to see how the transcriptional program of an entire organ has been modified to direct three key innovations in columbine flower development. My research has intensified my interest in the complex interactions controlling gene expression and their developmental consequences. Rather than simply turning a gene on or off, transcription factors, small RNAs, chromatin modifications, and nuclear architecture all interact to ensure a gene is expressed at the proper time and place, and that, consequently, the organism develops properly.

Publications

  • Karlova, R., F.M. Rosin, J. Busscher-Lange, V. Parapunova, A. Fernie, P.T. Do, A.R. Fernie, P.D. Fraser, C. Baxter, G.C. Angenent, and R.A. de Maagd. 2011. Transcriptome and metabolite profiling show that APETELA2a is a major regulator of tomato fruit ripening. Plant Cell 23: 923-941. (pdf)
  • Rosin, F.M. and E.M. Kramer. 2009. Old dogs, new tricks: Regulatory evolution in conserved genetic modules leads to novel morphologies in plants. Developmental Biology 332: 25-35. (pdf)
  • Rosin, F.M., W. Watanabe, J.L. Cacas, N. Kato, J.M. Arroyo, Y. Fang, B. May, M. Vaughn, J. Simorowski, U. Ramu, R.W. McCombie, D.L. Spector, R.A. Martienssen, and E. Lam. 2008. Genome-wide tagging reveals location-dependent effects on transcription and chromatin organization in Arabidopsis. Plant Journal 55: 514-525. (pdf)
  • Jovtchev, G., K. Watanabe, A. Pecinka, F.M. Rosin, M.F. Mette, E. Lam, and I. Schubert. 2008. Size and number of tandem repeat arrays can determine somatic homologous pairing of transgene loci mediated by epigenetic modifications in Arabidopsis thaliana nuclei. Chromosoma 117: 267-276. (pdf)
  • Schijlen, E.G.W.M., C.H.R. de Vos, S. Martens, H.H. Jonker, F.M. Rosin, J.W. Molthoff, Y.M. Tikunov, G.C. Angenent, A.J. van Tunen, and A.G. Bovy. 2007. RNA interference silencing of chalcone synthase, the first step in the flavonoid biosynthesis pathway, leads to parthenocarpic tomato fruits. Plant Physiology 144: 1520-1530. (pdf)
  • Rosin, F.M., N. Watanabe, and E. Lam. 2005. Moonlighting vacuolar protease: jobs for a busy protein. Trends in Plant Science 10: 516-518. (pdf)
  • Hannapel, D.J., H. Chen, F.M. Rosin, A.K. Banerjee, and P.J. Davies. 2004. Molecular controls of tuberization. American Journal of Potato Research 81: 263-274. (pdf)
  • Rosin, F.M., J.K. Hart, H. Van Onckelen, and D.J. Hannapel. 2003. Suppression of a vegetative MADS box gene of potato activates axillary meristem development. Plant Physiology 131: 1613-1622. (pdf)
  • Rosin, F.M., J.K. Hart, H.T. Horner, P.J. Davies, and D.J. Hannapel. 2003. Overexpression of a knotted-like homeobox gene of potato alters vegetative development by decreasing gibberellin accumulation. Plant Physiology 132: 106-117. (pdf)
  • Rosin, F.M., A. Aharoni, E.M.J. Salentijn, J.G. Schaart, M.J. Boone, and D.J. Hannapel. 2003. Expression patterns of a putative homolog of AGAMOUS, STAG1, from strawberry. Plant Science 165: 959-968. (pdf)
  • Chen, H., F.M. Rosin, S. Prat, and D.J. Hannapel. 2003. Interacting transcription factors from the three-amino acid loop extension superclass regulate tuber formation. Plant Physiology 132: 1391-1404. (pdf)
  • Graves, W.R., C.M. Foster, F.M. Rosin, and J.A. Schrader. 1999. Two early nodulation genes are not markers for the capacity of leguminous nursery crops to form root nodules. Journal of Environmental Horticulture 17: 126-129. (pdf)
  • Rosin, F.M., D.I. Shapiro, and L.C. Lewis. 1996. Effects of fertilizers on the survival of Beauvaria bassina. Journal of Invertebrate Pathology 68: 194-195. (pdf)